There are places in the city that are worse than others for performance but I’ve only ever noticed stutters and the like while driving. Do you use power utils? I don’t have an overclock but I make sure the governor is set to performance. Could just be luck on my end though.
Use the comments on protondb. They often list tweeks and troubleshooting steps that have been taken. Check steam community posts for specific games. You can also make your own post if nobody else has had your issue. General searches will usually get you where you need to go. I use kagi but generally anything not google works.