PFAS are used in so many forms (solvents, polymers, etc.) that I think the replacement will be very dependent on the specific use case (and potentially other regulations on alternatives, particularly for solvents). I’m not knowledgeable about every field these compounds are used in and for privacy/NDA purposes I can’t talk about the specifics of the ones I worked with.
For many applications, yes. Fluorinated compounds tend to be quite inert. There are definitely some applications where the compounds don’t need to be resistant to every type of chemical attack and you could use a more specialized compound that is generally less inert but performs similarly in whatever conditions you put it under.
Forever is a big part of the problem, but it’s worth noting that if a compound is completely nontoxic then bioaccumulation doesn’t matter as much (though some nontoxic chemicals can increase the potency of other, toxic chemicals and cause problems that way: see this article)
Yes. We need increased strictness on regulations and enforcement for these compounds and others because that’s the only way to make companies comply.